Fig. 4
From: Insights into high-risk multiple myeloma from an analysis of the role of PHF19 in cancer
Schema showing suggested mechanism of action of PHF19 overexpression in MM cell lines. Ren Z et al. showed that PHF19 promotes PRC2 activity and represses cell cycle inhibitor genes. Yu T et al. showed that PHF19 impedes PRC2 activity by promoting the phosphorylation of EZH2 via AKT pathway leading to EZH2 inactivation leading to an increase in expression of genes that play an important role in MM. Schinke C et al. showed that PHF19 repressed the expression of tumor suppressor protein (TSP) and upregulated the expression of pro-survival and proliferation genes