Fig. 2
The roles of METTL3 and ALKBH5 in LUAD tumorigenesis.(A) Schematic presentation of the construction of KP-based mice models and the principle timeframe for the experiments. (B) Tumor occurrence time in different KP-based mice models, as indicated. Mice were monitored from the 6th to 14th weeks post infection. (C) Representative images of H&E staining for lung bearing tumors in indicated KP-based mice models. Black arrow indicates tumor foci. (D-E) Number of tumors (D) and overall survival (E) in indicated KP-based mice models (n=6/group). (F-G) Representative images of lungs bearing tumors (F) and numbers of tumors in lung (G) from mice following tail injection of LLC cells with distinct modulations, as indicated. n=6/group, black arrow indicates tumor. (H-J) Images of xenografts that generated by H1975 cells under different modulations (H). The tumor weights (I) and volume (J) were also examined (n=8/group). Statistical analysis was performed using one-way ANOVA (B, D, G, I), log-rank test (E) and two-way ANOVA (J). Data are presented as means ± SEMs from indicated samples. **p < 0.01 and *p<0.05 indicates statistical significance