RNA N6-methyladenosine reader IGF2BP2 promotes lymphatic metastasis and epithelial-mesenchymal transition of head and neck squamous carcinoma cells via stabilizing slug mRNA in an m6A-dependent manner

Table 1 Association between IGF2BP2 expression and clinicopathological characteristics of patients with HNSCC

Characteristics	Total	IGF2BP2 expression		𝜒2	P Value
Characteristics	Total	High	Low	𝜒2	P Value
Age(y)				1.192	0.275
≥60	48	26	22
<60	30	20	10
Gender				0.448	0.504
Male	74	43	31
Female	4	3	1
T classification				1.184	0.757
T1	5	4	1
T2	13	8	5
T3	36	21	15
T4	24	13	11
N classification				8.804	0.032^*
N0	27	10	17
N1	10	6	4
N2	33	24	9
N3	8	6	2
Tumor Differentiation				2.096	0.351
Well	19	12	7
Moderate	39	20	19
Poor	20	14	6
Lymph node metastasis				8.214	0.004^*
No	27	10	17
Yes	51	36	15
Extranodal extension				0.115	0.734
No	67	39	28
Yes	11	7	4

Abbreviations: IGF2BP2 Insulin-like growth factor 2 mRNA-binding protein 2, HNSCC Head and neck squamous carcinoma cells
The P Value was measured by Chi-square test. *P < 0.05

ISSN: 1756-9966