Fig. 3
From: The CD70-CD27 axis in oncology: the new kids on the block
The CD70-CD27 axis and the tumor microenvironement. The CD70-CD27 axis facilitates immune evasion and suppression through different cell populations in the TME. The CD70-CD27 axis is reported to increase Treg survival and proliferation and T cell exhaustion and apoptosis. In addition, the axis has been linked to depletion of NK cells and migration/activation of TAMs. Moreover, expression of CD70 on CAFs can promote immune evasion through Treg accumulation and tumor migration and invasion. Figure created with BioRender.com. Abbreviations; Bcl2, B cell lymphoma 2; CAF, cancer-associated fibroblast; FoxP3, forkhead box P3; IL-2, interleukin 2; NK cell, natural killer cell; PD1, programmed cell death protein 1; sCD27, soluble CD27; Smad3, suppressor of mothers against decapentaplegic homolog 3; STAT5, signal transducer and activator of transcription 5; TAM, tumor-associated macrophage; TGF-β, transforming growth factor beta; TIL, tumor infiltrating lymphocyte; TIM-3, T cell immunoglobulin mucin-3; TME, tumor microenvironment; Treg, regulatory T cell