Fig. 6

In vivo results. A-C Decreased GRSF1 expression suppressed HCC xenograft tumor growth (*p<0.05, **p<0.01), while YY1 overexpression counteracted the inhibitory effect of GRSF1 knockdown (^#p<0.05, ^##p<0.01). D-F miR-30e-5p overexpression suppressed HCC xenograft tumor growth (*p<0.05, **p<0.01), YY1 overexpression or GRSF1 overexpression attenuated the inhibitory effect induced by pre-miR-30e-5p (^#p<0.05, ^##p<0.01), and cotransfection with pre-miR-30e-5p and sh-GRSF1 resulted in even smaller tumor sizes than transfection with pre-miR-30e-5p alone (^△p<0.05, ^△△p<0.01). Values are the mean± SEM (n=5)