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Fig. 6 | Journal of Experimental & Clinical Cancer Research

Fig. 6

From: The RNA-binding protein GRSF1 promotes hepatocarcinogenesis via competitively binding to YY1 mRNA with miR-30e-5p

Fig. 6

In vivo results. A-C Decreased GRSF1 expression suppressed HCC xenograft tumor growth (*p<0.05, **p<0.01), while YY1 overexpression counteracted the inhibitory effect of GRSF1 knockdown (#p<0.05, ##p<0.01). D-F miR-30e-5p overexpression suppressed HCC xenograft tumor growth (*p<0.05, **p<0.01), YY1 overexpression or GRSF1 overexpression attenuated the inhibitory effect induced by pre-miR-30e-5p (#p<0.05, ##p<0.01), and cotransfection with pre-miR-30e-5p and sh-GRSF1 resulted in even smaller tumor sizes than transfection with pre-miR-30e-5p alone (p<0.05, p<0.01). Values are the mean± SEM (n=5)

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