Fig. 9

Schematic diagrams depict that M1-like TAMs activated by exosome-THBS1 regulate the EMT/CSC cascades of OSCC cells by the IL6/STAT3/THBS1 axis. A. IL6 released by M1-like TAMs activates the STAT3 signaling in OSCC cells; B. A novel malignant loop demonstrates M1-like TAMs cascade a mesenchymal/stem-like phenotype of OSCC cells through the IL6/Jak/Stat3/THBS1 axis