Table 2 Baseline demographic and disease characteristic of patients (safety population, n = 44)
Baseline characteristic | Normal (Norm) (2 mg) | Mild (2 mg) | Moderate (Mod) DL1 (1.5 mg) | Moderate (Mod) DL+1 (2 mg) | Severe (Sev) DL1 (1 mg) | Severe (Sev) DL+1 (1.5 mg) | All Patients | |
|---|---|---|---|---|---|---|---|---|
Number of patients | 17 | 7 | 4 | 5 | 9 | 2 | 44 | |
Age, median (range) | 60 (40, 76) | 51 (27, 77) | 63 (60, 73) | 66 (39, 74) | 63 (38, 74) | 42.5 (42, 43) | 60 (27, 77) | |
Gender | Female | 11 | 4 | 0 | 2 | 2 | 1 | 20 |
Male | 6 | 3 | 4 | 3 | 7 | 1 | 24 | |
Performance status (ECOG) | 0 | 5 | 1 | 0 | 0 | 3 | 0 | 9 |
1 | 12 | 5 | 4 | 4 | 6 | 2 | 33 | |
2 | 0 | 1 | 0 | 1 | 0 | 0 | 2 | |
Cancer Type | Bile tract/Pancreas | 0 | 0 | 2 | 1 | 4 | 1 | 8 |
Liver | 1 | 0 | 1 | 3 | 1 | 0 | 6 | |
Lung | 4 | 1 | 0 | 0 | 0 | 0 | 5 | |
Uveal melanoma | 3 | 1 | 0 | 0 | 0 | 0 | 4 | |
Genitourinary (Bladder/Urethral/ Prostate) | 3 | 0 | 0 | 0 | 0 | 0 | 3 | |
Skin | 1 | 1 | 0 | 0 | 1 | 0 | 3 | |
Breast | 0 | 2 | 0 | 0 | 0 | 0 | 2 | |
Esophagus | 0 | 1 | 0 | 0 | 1 | 0 | 2 | |
Ovary | 2 | 0 | 0 | 0 | 0 | 0 | 2 | |
Thyroid | 1 | 0 | 1 | 0 | 0 | 0 | 2 | |
Others | 2 | 1 | 0 | 1 | 2 | 1 | 7 | |
Number of Prior Regimens | ||||||||
≤2 | 4 | 4 | 2 | 3 | 2 | 0 | 15 | |
>2 | 13 | 3 | 2 | 2 | 7 | 2 | 29 |