Fig. 6
From: The SF3B1R625H mutation promotes prolactinoma tumor progression through aberrant splicing of DLG1
The SFB31/DLG1 axis promoted tumor invasion via the PI3K/AKT signaling pathway. A KEGG enrichment analysis of DEGs in SF3B1 mutant vs. wild-type human prolactinoma and GH3 cells. B Phosphorylated and total AKT and GSK-3β levels in Sf3b1 WT and mutant GH3 cells transduced with or without Dlg1-FLAG cDNA. C Phosphorylated and total AKT and GSK-3β levels in GH3, 293 T, and MCF7 cells transduced with or without DLG1 siRNA