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Fig. 1 | Journal of Experimental & Clinical Cancer Research

Fig. 1

From: TRPM7 silencing modulates glucose metabolic reprogramming to inhibit the growth of ovarian cancer by enhancing AMPK activation to promote HIF-1α degradation

Fig. 1

TRPM7 promotes the growth of ovarian cancer. A A volcano plot displayed the DEGs between sh-control SKOV3 and sh-TRPM7 SKOV3 cells. B GSEA analysis predicted that TRPM7 was involved in cell cycling and positive regulation of cell mitosis and acute inflammatory. C EdU assay exhibited that TRPM7 silencing inhibited cell proliferation. Scale bar = 50 μm. D TRPM7 silencing inhibited the growth of xenograft SKOV3 in vivo. E GO analysis exhibited that the DEGs were enriched in the indicated biological processes in the TRPM7 silencing SKOV3 cells. F Circos plot displayed the relationships between the DEGs and potential functions in TRPM7 silencing SKOV3 cells. (G) GSEA analysis predicted that TRPM7 was involved in the AMPK pathway

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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