HDAC7 promotes NSCLC proliferation and metastasis via stabilization by deubiquitinase USP10 and activation of β-catenin-FGF18 pathway

Table 1 Correlation of HDAC7 and FGF18 expression with clinicopathological characteristics of NSCLC patients

Clinicopathological Variables	n	Tumor HDAC7 expression		P value	Tumor FGF18 expression		P value
Clinicopathological Variables	n	Low	High	P value	Low	High	P value
Age
≥ 60	174	119	55	0.776	104	70	0.586
< 60	145	97	48	0.776	91	54	0.586
Sex
Female	61	41	20	0.926	37	24	0.933
Male	258	175	83	0.926	158	100	0.933
Smoking history
Never	103	68	35	0.655	61	42	0.630
ever	216	148	68	0.655	134	82	0.630
Maximal tumor size
< 5 cm	118	89	29	0.024	82	36	0.019
≥ 5 cm	201	127	74	0.024	113	88	0.019
T stage
T1-T2	130	103	27	< 0.001	94	36	0.001
T3-T4	189	113	76	< 0.001	101	88	0.001
Lymphatic invasion
N0	146	110	36	0.007	103	43	0.002
N1-N3	173	106	67	0.007	92	81	0.002
Distant metastasis
No	309	214	95	0.001	192	117	0.040
Yes	10	2	8	0.001	3	7	0.040
TNM stages
I	47	44	3	< 0.001	35	12	< 0.001
II	96	71	25		76	20
III	166	99	67		81	85
IV	10	2	8		3	7
Tumor differentiation
High and moderate	219	161	58	0.001	145	74	0.006
poor	100	55	45	0.001	50	50	0.006

ISSN: 1756-9966