Fig. 1

ZNF498 is highly expressed in human HCC tissues. A ZNF498 mRNA levels in 50 paired human HCC specimens and adjacent normal tissues from the TCGA database were analyzed. B Kaplan–Meier plots of the overall survival of patients with low and high expression levels of ZNF498 mRNA in tumor tissues (cut off =1.1) from the TCGA datasets. C ZNF498 mRNA levels in 35 paired human HCC tissues and adjacent normal tissues were analyzed using RNA-seq data available online. D ZNF498 protein levels in 14 pairs of HCC and adjacent normal tissue samples were detected by Western blotting. T, tumors; A, adjacent normal tissues. E Statistical analysis and representative images of ZNF498 expression in 86 paired HCC tissues and adjacent normal tissues as detected by IHC. F Statistical analysis and representative images of ZNF498 expression in HCC tissues (n = 92) with different histological grades as detected by IHC. G Kaplan–Meier survival curves according to ZNF498 expression level in HCC tissues (n = 92) as detected by IHC. Scale bars, 20 μm. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001