Table 3 Non-coding RNAs regulating autophagy in prostate cancer

MIR124

MIR144

PIM1, autophagy

Inhibition

Hypoxia provides downregulation of MIR124 and MIR144 via disrupting DICER1 expression.

Enhancing miRNA expression inhibits autophagy via PIM1 downregulation, leading to enhanced radio-sensitivity of prostate cancer cells.

[299]

MIR301A/B

NDRG2, autophagy

Induction

Increased expression of MIR301A/B in the presence of hypoxia.

Binding to 3′-UTR of NDRG2 and reducing its expression.

Autophagy induction and enhancing prostate cancer cell viability.

[300]

MIR96

MTOR, autophagy

ATG7, autophagy

Induction

Inhibition

Dual role of MIR96 in prostate cancer cells and autophagy regulation during hypoxia.

Autophagy induction via inhibiting MTOR signaling.

Autophagy inhibition via ATG7 downregulation.

[301]

MIR205

RAB27A

LAMP3

Inhibition

Downregulation of RAB27A and LAMP3 in autophagy inhibition.

Impairing proliferation and enhancing chemosensitivity of prostate cancer cells.

[302]

MIR34A

AMPK-MTOR-ATG4B

Inhibition

Reducing AMPK phosphorylation.

Inducing MTOR signaling.

Autophagy inhibition via ATG4B downregulation.

Enhancing prostate cancer progression and reducing chemosensitivity.

[303]

LncRNA SNHG12

MIR195-CCNE1

Inhibition

Overexpression of SNHG12 in prostate cancer cells.

Association with poor prognosis.

Reducing MIR195 expression via sponging.

Activation of PI3K-AKT-MTOR signaling.

Reducing apoptosis and autophagy.

[304]

LncRNA PRRT3-AS1

PPPARG, autophagy

Inhibition

PARP downregulation in impairing autophagy.

Enhancing proliferation of prostate cancer cells and reducing apoptosis.

[288]

Circ-CCNB2

MIR30B-5p-KIF18A

Induction

Reducing MIR30B-5p expression via sponging.

Enhancing KIF18A expression.

Autophagy induction and subsequent resistance to radiation therapy.

[298]