Fig. 4

MiR-34c levels during NPC progression and target genes validation. a The expression level of miR-34c-5p in human NPC specimens compared with control biopsy samples. b miR-34c-5p expression was higher in stage I, whereas stages II-IV had lower levels. c The protein expression levels of MET, CCND1, CDK6 and BCL2 in miR-34c mimic transfected CNE-2 cells were lower than the controls. Western blot was independently repeated at least three times. MicroRNA abundance was normalised to U6 RNA. Statistical analysis was performed using the t-tests (a, c) and the one-way ANOVA (b)