Table 1 Classification and function of cohesin subunits
Gene | Saccharomyces cerevisiae | Drosophila melanogaster | Function |
|---|---|---|---|
ESCO1/2 | Eco1/Ctf7 | Deco | Acetyltransferases, establishment of cohesion |
HDAC8 | Â | Â | SMC3 deacetylase |
NIPBL | Scc2 | Nipped-B | Cohesin loading |
PDS5A | Pds5A | Pds5 | Cohesin dissociation |
PDS5B | Â | Â | Cohesin dissociation |
RAD21 | Mcd1/Scc11 | Rad21 | Core cohesin subunit |
STAG1 | Irr1 | Sa | Cohesin subunit |
STAG2 | Scc3 | Sa2/Stromalin | Cohesin subunit |
MAU2 | Scc4 | Mau2 | Cohesin loading |
SECURIN (PTTG1) | Pds1 | Pim | Separase inibitor |
SEPARASE (ESPL1) | Esp1 | Sse | Cohesin cleavage |
SMC1A | Smc1 | Smc1 | Core cohesin subunit |
SMC3 | Smc3 | Cap | Core cohesin subunit |
USP37 | Â | Â | Cohesin dissociation |
WAPL | Rad61/Wpl1 | Wapl | Cohesin dissociation |