Fig. 4
From: The role of TBK1 in cancer pathogenesis and anticancer immunity
TBK1 regulates selective autophagy and xenophagy. TBK1 is activated during autophagy and xenophagy. Activated TBK1 promotes selective autophagy and xenophagy by phosphorylating some of the autophagic modifiers and receptors. This drives cargoes into autophosomes via interactions with both the cargoes and LC3. Interestingly, TBK1 accumulation on damaged cargo suppresses mitosis due to reduced TBK1 interactions with the key regulators of mitosis, NuMA and CEP170