Fig. 1

Synchronous metastatic tumors exhibit heterogeneous growth and somatic mutation and neoantigen patterns. a Anatomical map of representative biospecimen collection sites in the patient. b Representative CT and MRI scans of different resected tumors: primary lung tumor, cervical lymph node enlargement, liver metastasis and C5 spine compression fracture by metastasis. c Non-silent mutation counts in tumors. d Fraction of shared and unique non-silent mutations across tumors