Fig. 4

Evolution of synchronous metastases may be shaped by the T cell repertoire. a Quantification of T cell repertoire heterogeneity across tumors by Jaccard index (JI). b Quantification of predicted neoantigen heterogeneity across tumors by JI. c Correlation between T cell repertoire JI and predicted neoantigen JI. d Deconvolution of immune components and T cell subpopulations by MethylCIBERSORT. e Correlation between T-cell richness and estimated CD8⁺ Tcell fraction. f Correlation between T-cell clonality and estimated CD8⁺ Tcell fraction