Fig. 7

BGA002-RA inhibits vascularization of MNA-NB and improves survival in mice. A Kaplan-Meyer plot for the probability of event-free survival over time for CHP-134-luc (MYCN amplified, p53 wild type) xenograft mice treated with: vehicle (black line, n = 10), 13-cis RA 10 mg/kg/day (yellow line, n = 12), BGA002 10 mg/kg/day (red line, n = 12), 13-cis RA and BGA002 10 mg/kg/day (orange line, n = 13). In the middle of the plot is the associated p-value (log-rank test) *, p < 0.05. B immunohistochemistry analysis of neuroblastoma mice untreated (first column), treated with 13-cis RA 10 mg/kg/day (second column), treated with BGA002 10 mg/kg/day (third column), 13-cis RA and BGA002 10 mg/kg/day (fourth column). The first row shows staining with hematoxylin and eosin (H&E), the second row is the N-Myc antibody, and the third row Ki67 staining