Fig. 8
From: TEAD4 functions as a prognostic biomarker and triggers EMT via PI3K/AKT pathway in bladder cancer
TEAD4 promotes EMT in BLCA cells via PI3K/AKT signaling pathway (A) Representative data from Transwell migration and Matrigel invasion assays performed in the indicated cells treated with or without LY294002 (5637, 4 × 104 cells, 24 h; TCCSUP, 4 × 104 cells, 48 h). (B) Representative data from wound healing migration assays performed in the indicated cells treated with or without LY294002. (C) Relative expression levels of E-cadherin, N-cadherin, Vimentin, Snail, p-AKT and GAPDH in the indicated cells treated with or without LY294002. (D) Representative data from Transwell migration and Matrigel invasion assays performed in the indicated cells treated with or without 740Y-P (T24, 2 × 104 cells, 36 h; 5637, 4 × 104 cells, 36 h). (E) Representative data from wound healing migration assays performed in the indicated cells treated with or without 740Y-P. (F) Relative expression levels of E-cadherin, N-cadherin, Vimentin, Snail, p-AKT and GAPDH in the indicated cells treated with or without 740Y-P. Data are expressed as mean ± SD (*p < 0.05; **p < 0.01; ***p < 0.001)