Fig. 9
G9a targeting inhibits KRASG12D induced malignant traits in CCA cells: identification of G9a as a therapeutically relevant vulnerability in KRASG12D expressing CCA cells. a Anchorage-independent growth of control and KRASG12D expressing (MutKRAS) Huh28 cells treated or not with CM-272 (200 nM). Representative images of colonies formed at the end of experiments (3 weeks) and quantification of the area occupied by colonies are shown. ***p < 0.001. b Colony formation assay in control and MutKRAS Huh28 cells treated with CM-272 as indicated. Representative images of crystal violet-stained colonies and the corresponding quantification are shown. *p < 0.05, **p < 0.01