Fig. 5

HuR binds to the 3′UTR of FOXM1 and regulates its transcription. a and b Pearson's correlation scatter plots for FOXM1-SOCS7 (a) and FOXM1-HuR (b) of HGSOC patients (n = 30) in cohort 1. c Additional HuR RIPs followed by qRT-PCR on precipitates validated HuR binding of FOXM1 mRNA in CAOV3 cells transduced with indicated lentiviral vectors. d Relative luciferase activity of FOXM1 3'UTR in CAOV3 cells transduced with indicated lentiviral vectors. e Relative mRNA levels of FOXM1 in CAOV3 cells transduced with indicated lentiviral vectors and treated with 5 μg/ml actinomycin D. f-i HuR and FOXM1 expression in CAOV3 cells transduced with indicated lentiviral vectors. *P < 0.05, **P < 0.01 and ***P < 0.001, in related with shNC, Vector. ^###P < 0.001, in related with SOCS7