Fig. 1

RYR1 is significantly upregulated in USC. A Flow chart for identifying differential expressed genes from TCGA dataset that are associated with. USC development including normal control (n = 35), EEC (n = 409) and USC (n = 115). FC=Fold Change, HR = Hazard Ratio, OS=Overall Survival, N = number of sample, n = number of gene. B Relative RYR1 mRNA levels in USC, EEC, and UE cells detected by ddPCR. C Western blot of RYR1 protein in the indicated USC and UE cells