Skip to main content

Retraction Note: microRNA-15b-5p encapsulated by M2 macrophage-derived extracellular vesicles promotes gastric cancer metastasis by targeting BRMS1 and suppressing DAPK1 transcription

The Original Article was published on 22 April 2022

Retraction Note: J Exp Clin Cancer Res 41, 152 (2022)

https://doi.org/10.1186/s13046-022-02356-8

The authors have retracted this article. After publication, the authors realized there were potential errors with figure labels and the cell lines used in the experiments. Additional checks have identified that:

  1. 1.

    Fig. 1c states that co-localization of CD206 and miR-15b-5p is presented, but only images for miR-15b-5p and DAPI are presented.

  2. 2.

    Fig. 1i blots appear to have deleted backgrounds and an artifact in the Calnexin image.

  3. 3.

    Figs. 1b, 3e and 5c use SGC-7901 cells, which are contaminated with HeLa.

  4. 4.

    Fig. 5i MKN-45 data don’t appear to match Fig. S2c.

  5. 5.

    Fig. 7c AGS BRMS1 data don’t appear to match Fig. S2f.

  6. 6.

    Fig. S2a MKN-45 VIM lanes 1 and 2 have similar artifacts on the right side of the bands.

  7. 7.

    The study did not obtain ethics approval prior to the start of the experiment.

The authors have been able to provide alternative data for Figs. 1i, S2a, c and f to address some of these concerns. However, the cell line and ethics issues could not be resolved.

All authors agree to this retraction.

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to Zhigang Jie or Zhengrong Li.

Rights and permissions

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Cao, Y., Tu, Y., Xiong, J. et al. Retraction Note: microRNA-15b-5p encapsulated by M2 macrophage-derived extracellular vesicles promotes gastric cancer metastasis by targeting BRMS1 and suppressing DAPK1 transcription. J Exp Clin Cancer Res 41, 213 (2022). https://doi.org/10.1186/s13046-022-02426-x

Download citation

  • Published:

  • DOI: https://doi.org/10.1186/s13046-022-02426-x