Fig. 6
![Fig. 6](http://media.springernature.com/full/springer-static/image/art%3A10.1186%2Fs13046-022-02429-8/MediaObjects/13046_2022_2429_Fig6_HTML.png)
SH3GLB1-knockdown resistant cells regain treatment benefit from TMZ in the xenograft mouse model. A The bioluminescent signal from the luciferase-carrying U87MG-R cells in tumor carrying mice was detected using an IVIS imaging system and plotted (N = 6 in each group, *p < 0.05). B The protein immunoblot of the tumor showing SH3GLB1 and the proteins related to autophagy and OXPHOS (N = 3 in each group). C Kaplan-Meier plot showing the survival curves of the orthotopic animals in each group (N = 6 in each group, *p < 0.05). D The working scheme of SH3GLB1-regulated OXPHOS for TMZ resistance