From: Noncoding RNAs as sensors of tumor microenvironmental stress
NcRNAs | Expression in inflammation | Regulatory mechanisms | Functions | Cancer types | References |
---|---|---|---|---|---|
miRNA-21 | Up-regulated | IL-6/STAT3, IFN/JAK/STAT3 or IFN/NF-κB | Promote metastasis, modulate immune response | Multiple cancer types | |
miRNA-17–92 | Up-regulated | IL-6/STAT3 | Enhance proliferation, and invasiveness | Cholangiocarcinoma | [75] |
miRNA-146b | Up-regulated | IL-6/STAT3 | Inhibit migration and invasion | Breast cancer | [76] |
lncRNA TCF7 | Up-regulated | IL-6/STAT3 | Promote EMT | Hepatocellular carcinoma | [77] |
lncRNA DANCR | Up-regulated | IL-6/STAT3 | Promote sorafenib resistance | Hepatocellular carcinoma | [78] |
lncRNA Morrbid | Up-regulated | IL-6/STAT3 | Inhibit apoptosis | Acute myeloid leukemia | [79] |
lncRNA ZEB2-AS1 | Up-regulated | IL-6/STAT1 | Enhance migration | Non-small cell lung cancer | [80] |
circRNA cGGNBP2 | Up-regulated | Circularization inhibition via DHX9 | Promote cell growth and metastasis | Intrahepatic cholangiocarcinoma | [81] |
lncRNA MALAT1 | Up-regulated | IL-6/STAT3, IL-8/STAT3 or CCL21 | Promote cell proliferation and metastasis | Multiple cancer types | |
miRNA-181a | Up-regulated | IL-1β/NF-κB | Promote cell proliferation | Colorectal cancer | [86] |
miRNA-425 | Up-regulated | IL-1β/NF-κB | Promote cell proliferation | Gastric cancer | [87] |
lncRNA NKILA | Up-regulated | TNF-α/NF-κB | Suppress proliferation, metastasis | Breast cancer; laryngeal cancer | |
circRNA SND1 | Up-regulated | TNF-α/NF-κB | Promote migration and invasion | Cervical cancer | [90] |
miRNA-130a | Up-regulated | TNF-α/NF-κB | Promote cell growth | Cervical cancer | [91] |
lncRNA AC007271.3 | Up-regulated | TNF-α/NF-κB | Promote proliferation, migration, invasion, and inhibit apoptosis | Oral squamous cell carcinoma | [92] |
lncRNA HOTAIR | Up-regulated | TNF-α/NF-κB or CCL18 | Promote proliferation, angiogenesis, drug resistance | Multiple cancer types | |
lncRNA LOC105374902 | Up-regulated | TNF-α/STAT3 | Facilitate EMT process, migration, invasion | Cervical cancer | [95] |
lncRNA IRF1-AS | Up-regulated | IFN/JAK/STAT | Inhibit proliferation and promote apoptosis | Esophageal squamous cell carcinoma | [96] |
lncRNA GAS5 | Up-regulated | IFN/JAK/STAT | Inhibit proliferation, migration, and invasion | Esophageal squamous cell carcinoma | [97] |
lncRNA LINC00092 | Up-regulated | CXCL14 | Promote glycolysis and metastasis | Ovarian cancer | [98] |
lncRNA XIST | Up-regulated | CXCL12/CXCR4 | Promote invasion and metastasis | Colorectal cancer | [99] |
lncRNA LINC00319 | Up-regulated | CCL18 | Promote proliferation and metastasis | Oral squamous cell carcinoma | [100] |
circRNA circ_0026344 | Down-regulated | CCL20 and CXCL8 co-stimulation | Restrain metastasis | Colorectal cancer | [101] |