Fig. 2

High grade serous ovarian cancers show heterogeneous patterns of genome-wide methylation: A Both primary and recurrent tumors show heterogeneous patterns of methylation across the genome, with many tumors showing extensive hypomethylation on the X chromosome (CpG values are averaged across 10kB windows, minus ENCODE ‘blacklist’ regions); B Examples of two regions on chromosome 1q42.13 and 22q13.33, that show differentially methylated regions (boxed regions) from two comparisons—Primary vs Recurrent tumors (left) and BRCA1/2 carrier vs BRCA1/2 non-carrier (right)