Fig. 2

The match-subject analysis identifies global protein-mRNA concordance as an OABL-associated characteristic. A Schematic diagram of global protein-mRNA concordance calculation. B Density plot showing the global Spearman correlation for protein-mRNA pairs within OABLs (n = 3818 protein-mRNA pairs) and controls (n = 3728 pairs). C Concordance of protein-mRNA pairs is significantly higher in OABLs compared with the control or normal group and relatively higher compared with the RLP or IOI group. D Global protein-mRNA concordance is associated with prognostic risk factors. No-EMZL subtype, high LDH, and high IPI score have an increased concordance. E Global protein-mRNA concordance is positively correlated with the MKI67 proteomic abundance in the OABLs (r = 0.495, p = 0.005) but not in the controls (r = 0.203, p = 0.527). Blue line shows liner regression. F High global protein-mRNA concordance is associated with distant recurrence in OABL. G Kaplan-Meier plot shows high global concordance in OABLs is associated with decreased distant recurrence-free survival. H Bar plot of top 20 gene sets identified by GSVA correlated with global protein-mRNA concordance