Fig. 3

Establishment of inflammation-OABL protein signature. A PCA of high variant proteins (protein with top 25% median absolute deviation). B boxplot of Dim1 showing difference between normal, inflammation, and OABL groups. C Heatmap of NFkB pathway analyzed by proteomic data. D Heatmap of k-means clustering result of highly variant proteins (protein with top 50% median absolute deviation). E Facet plot showing the trend of protein abundance of each k-means cluster between groups. Each dot represents the median protein z-score for one sample in each cluster. The blue lines indicate the segmented linear regression between two adjacent groups, and the blue numbers indicate the slope value of the regression. The red lines indicate linear regression for all groups, and the red numbers indicate the slope value of the regression. The numbers in black indicate the percentage of genes in the cluster compared to all genes analyzed. F Facet plot shows nine patterns of protein expression changes across groups identified by t-test. Black numbers indicate the percentage of genes in the cluster compared to all genes analyzed. G Alluvial plot showing the process of inflammation-OABL protein signature establishment. H Bar plot of top 20 enrichment terms of Specific up signature and Mimic up signature