Fig. 9
From: Suppression of VEGFD expression by S-nitrosylation promotes the development of lung adenocarcinoma
An integrated working model for S-nitrosylation-negated VEGFD in lung adenocarcinoma. Excessive NO and low expression of GSNOR in lung adenocarcinoma exacerbate S-nitrosylation of VEGFD at Cys277, suppressing its expression by affecting stability, while S-nitrosylation of VEGFD also affects its secretion, meanwhile NO promotes VEGFA, VEGFA and VEGFD compete for binding to VEGFR2 to promote angiogenesis