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Table 1 Univariate and Multivariate Analysis of YAP1/FAPα and Clinical Characteristics for Metastasis-Free Survival of NPC Patients

From: Epstein-Barr viral product-containing exosomes promote fibrosis and nasopharyngeal carcinoma progression through activation of YAP1/FAPα signaling in fibroblasts

YAP1 Univariate analysis   Multivariate analysis  
n = 106 HR (95% CI) p value HR (95% CI) p value
YAP1 Score (≥80 vs. < 80) 2.470 (1.057–5.776) 0.037 4.834 (1.857–12.579) 0.001
Treatment Daysa 1.105 (1.008–1.21) 0.032 1.190 (1.069–1.325) 0.001
BEDa 1.05 (0.875–1.155) 0.945 0.896 (0.772–1.040) 0.148
Age Group (≥48 vs. < 48) 0.830 (0.372–1.853) 0.65 0.727 (0.258–2.046) 0.546
Gender (Male vs. Female) 2.806 (0.837–9.410) 0.095 4.020 (1.007–16.059) 0.049
T-Stage (T3/4 vs. T1/2) 1.519 (0.675–3.419) 0.313 2.085 (0.750–5.800) 0.159
N-Stage (N2/3 vs. N0/1) 1.717 (0.762–3.867) 0.192 1.989 (0.817–4.843) 0.13
Chemotherapy (Yes vs. No) 0.891 (0.332–2.385) 0.818 0.616 (0.207–1.832) 0.384
Comorbidity (Yes vs. No) 1.161 (0.516–2.615) 0.718 1.416 (0.543–3.693) 0.477
Smoking (Yes vs. No) 1.516 (0.663–3.465) 0.324 1.098 (0.413–2.916) 0.851
Betel quid (Yes vs. No) 1.619 (0.671–3.905) 0.283 1.353 (0.382–4.798) 0.64
Alcohol (Yes vs. No) 1.263 (0.561–2.845) 0.572 0.913 (0.300–2.780) 0.873
FAPα Univariate analysis   Multivariate analysis  
n = 143 HR (95% CI) p value HR (95% CI) p value
FAPα Score (≥80 vs. < 80) 2.221 (0.995–4.959) 0.051 2.867 (1.127–7.291) 0.027
Treatment Daysa 1.070 (0.994–1.152) 0.072 1.078 (0.984–1.180) 0.105
BEDa 1.036 (0.952–1.127) 0.417 0.991 (0.911–1.078) 0.835
Age Group (≥48 vs. < 48) 0.742 (0.332–1.656) 0.466 0.526 (0.196–1.409) 0.201
Gender (Male vs. Female) 4.424 (1.040–18.813) 0.044 6.189 (1.334–28.724) 0.02
T-Stage (T3/4 vs. T1/2) 2.037 (0.871–4.762) 0.01 2.031 (0.748–5.512) 0.164
N-Stage (N2/3 vs. N0/1) 2.782 (1.153–6.710) 0.023 2.756 (1.111–6.833) 0.029
Chemotherapy (Yes vs. No) 0.730 (0.290–1.840) 0.505 0.594 (0.211–1.670) 0.323
Comorbidity (Yes vs. No) 1.392 (0.577–3.357) 0.462 1.047 (0.396–2.769) 0.926
Smoking (Yes vs. No) 1.114 (0.495–2.508) 0.794 0.482 (0.184–1.264) 0.138
Betel quid (Yes vs. No) 1.454 (0.603–3.508) 0.404 1.231 (0.403–3.762) 0.715
Alcohol (Yes vs. No) 1.181 (0.505–2.759) 0.701 0.928 (0.289–2.983) 0.9
  1. acontinuous variable; BED, Biologically effective dose, HR Hazard ratio, CI Confidence interval