Fig. 4

CCDC6 downregulation can restore the olaparib sensitivity in resistant ovarian cancer cells. A Drugs sensitivity and surviving fraction in OVCAR3 olaparib Resistant (OVCAR3 olaR) and OV-90 olaparib Resistant (OV-90 olaR) cells, compared to the parental OVCAR3 and OV-90 cells, after 144 h exposure to different doses of Olaparib and Cisplatin. B In the figure, the CI values, according to 1:2 concentration ratio of Cisplatin and Olaparib, are reported. C, D IC50 values and surviving fraction of OVCAR3 olaR and OV-90 olaR cells, compared to parental OVCAR3 and OV-90 cells, after 144 h exposure to Olaparib and Cisplatin, in presence or absence of P5091, are displayed. E In OV-90 olaR, the CI values according to 1:2 concentration ratio of Cisplatin and Olaparib, in presence or absence of P5091 [2.5 μM] are shown