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Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: APE1 redox function is required for activation of Yes-associated protein 1 under reflux conditions in Barrett’s-associated esophageal adenocarcinomas

Fig. 5

E3330 reduces PDX tumor growth and YAP1 activation. A Average tumor volume of PDX with or without 20 mg/kg E3330 treatment for 28 days (Control: 5mice; E3330: 5mice). B Kaplan–Meier survival curve for PDX following treatment endpoint. C Average weight of control and E3330 treated PDXs over 28 days of treatment. D Representative immunohistochemistry staining images of APE1 and YAP1 in PDX mouse tissues with or without E3330 treatment. Quantification of immunofluorescence intensity by ImageJ is also shown. E Representative immunofluorescence images of CTGF (green) in PDX mouse tissues with or without E3330 treatment. DAPI (blue) was used for nuclear staining

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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