Fig. 5

Relative expression of immune-related genes is associated with outcomes of vestibular schwannoma (VS). A Expression differences in pairs of genes are represented in green (“True”) if the expression of the first gene was higher than that of the second gene or in orange (“False”) otherwise. KTSP classification (top row) was calculated by summing votes for each gene pair; red indicates predicted late recurrence, and blue indicates predicted early recurrence. The bottom row indicates the correct group for each sample; L indicates late recurrence, and E indicates early recurrence. The KTSP model correctly categorized all 8 of the patients with early recurrence and 7 of the 9 patients with late recurrence. B The scatter plots show the expression levels of each gene pair (individual genes in each pair are indicated on the y- and x-axes, respectively) in each of the 17 VS patients. The black line represents the gene-pair classification boundaries; samples represented above the line have higher expression of the y-axis gene than the x-axis gene and are classified as “True,” and samples below the line have higher expression of the x-axis gene than the y-axis gene and are classified as “False.” Blue triangles and red circles indicate samples from patients with early VS recurrence and those with late VS recurrence, respectively