Fig. 6

Decreased adaptive immune response in activated CD8⁺ T cells co-cultured with schwannoma cells. A Principal Component Analysis of a population of activated CD8⁺ T cells with (orange) and without (blue) co-cultured schwannoma cells. B Heat map demonstrating the difference in proteomic profile expression in activated CD8⁺ T cells with and without co-cultured schwannoma cells. C Cumulative polyfunctionality metric of activated CD8⁺ T cells with and without co-cultured schwannoma cells. D Single marker expression distribution in activated CD8⁺ T cells cultured alone (blue) or co-cultured with VS cells (orange). E Activated CD8⁺ T cell functional subset abundance in the presence or absence of VS cells. Note that the CD8⁺ T cells cultured with VS lost expression of their functional markers (grey)