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Table 1 List of tribodies generated in the study

From: Novel tri-specific tribodies induce strong T cell activation and anti-tumor effects in vitro and in vivo

Name of product Structure   Fab scFv
Tb535H (Fab) 5T4 – (scFv) CD3 – (scFv) 5T4 H – chain derivative hu5T4 huOKT3
L – chain derivative hu5T4 hu5T4
53L1 (Fab) 5T4 – (scFv) CD3 – (scFv) PD-L1 H – chain derivative hu5T4 huOKT3
L – chain derivative hu5T4 PD-L1_1
53L10 (Fab) 5T4 – (scFv) CD3 – (scFv) PD-L1 H – chain derivative hu5T4 huOKT3
L – chain derivative hu5T4 10_12
53D (Fab) 5T4 – (scFv) CD3 – (scFv) PD-1 H – chain derivative hu5T4 huOKT3
L – chain derivative hu5T4 PD-1_1
53G (Fab) 5T4 – (scFv) CD3 – (scFv) LAG-3 H – chain derivative hu5T4 huOKT3
L – chain derivative hu5T4 LAG-3_1
53P (Fab) 5T4 – (scFv) CD3 – (scFv) Palivizumab H – chain derivative hu5T4 huOKT3
L – chain derivative hu5T4 Palivizumab
  1. Amino acidic sequences of Tb535H were described in WO2016097408 (A1). Amino acidic sequences of PD-1_1, PD-L1_1, 10_12, LAG-3_1 were described in WO2019180201A2