Table 2 Key protein signalling pathways and phosphorylated proteins characteristics of each triple negative breast cancer subtype as derived from phospho-proteomics
TNBC subtype | Key phospho-proteomic characteristics |
|---|---|
Luminal androgen receptor | PI3K/AKT signalling (AKT1, AKT2) RB (retaining low levels of E2F) MAP2K4 Androgen receptor activity (AR, SREBF1) Fatty acid metabolism |
Mesenchymal | DNA repair signalling (ATM, ATR) |
Basal-like immune suppressed | Cell cycle (CDK1) VRK1 |
Basal-like immune activated | PKN1 PRKD2 STAT signalling (STAT1, STAT2, STAT5A) |