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Fig. 9 | Journal of Experimental & Clinical Cancer Research

Fig. 9

From: PCSK9 promotes the progression and metastasis of colon cancer cells through regulation of EMT and PI3K/AKT signaling in tumor cells and phenotypic polarization of macrophages

Fig. 9

Illustration of PCSK9 oncogenic activity in colon cancer. PCSK9 protein promotes colon cancer cell proliferation and metastasis by activation of the PI3K/AKT pathway and tumor cell EMT. PCSK9 also induces M2 macrophage polarization might through changes in lactate and MIF levels; thus, PCSK9 inhibition could reverse this trend; thereby enhancing human body antitumor immunity

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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