Fig. 6

SiLINC01132 improves the response to anti-PDL1 immunotherapy in a subgroup of HCC. A Scatter plots showing the correlation between LINC01132 expression and CD8+ T cells infiltrations. B Mice were orthotopically xenografted with Hep1–6 injection and treated with anti-PDL1 or IgG or siLINC01132 plus anti-PDL1. Bottom panel showing representative images of tumors treated with IgG + shLINC01132 or anti-PDL1 + shLINC01132. C-D The tumor volume and weight of mice treated with IgG + shLINC01132 or anti-PDL1 + shLINC01132. C for tumor volume and D for tumor weight. E IHC staining of CD8A and the number of CD8A positive cells. F The mechanistic scheme of lncRNA LINC01132/NRF1/DPP4 axis in HCC