Fig. 4
From: Peptide-based PROTAC degrader of FOXM1 suppresses cancer and decreases GLUT1 and PD-L1 expression
FOXM1-PROTAC inhibits proliferation, migration and invasion of cancer cells. A Analysis for DNA content of HepG2 and MDA-MB-231 cells on a Flow cytometer, treated with FIP-1 and FOXM1-PROTAC for 24 h and stained with propidium iodide. B Scratch assay of HepG2 and MDA-MB-231 cells, which were treated with FIP-1 and FOXM1-PROTAC for 24 h. C Colony formation results and analysis of HepG2 and MDA-MB-231 cells, which were treated with FIP-1 and FOXM1-PROTAC for 24 h and cultured for 14 days. D Transwell experiment and Statistical histogram, which reflects different invasion ability of HepG2 and MDA-MB-231 cells treated with FIP-1 and FOXM1-PROTAC for 24 h. E Examination of E-cadherin, N-cadherin and Vimentin level of HepG2 and MDA-MB-231 cells, treated with FIP-1 and FOXM1-PROTAC for 48 h