Fig. 3
From: Elesclomol: a copper ionophore targeting mitochondrial metabolism for cancer therapy
Cancers highly dependent on mitochondrial metabolism. Cancers such as melanoma, breast cancer, and ovarian cancer show spontaneous enhancement of mitochondrial metabolism. Cancer stem cells of glioblastoma, ovarian cancer, cholangiocarcinoma, and other cancers highly depend on mitochondrial metabolism. Increased dependence on mitochondrial metabolism is seen in drug-resistant cancer cells generated in some anticancer treatments, including cisplatin-resistant melanoma and hepatocellular carcinoma from conventional chemotherapies and 5-FU-resistant colon cancer, BRAF inhibitor-resistant melanoma from molecularly targeted drugs, and EGFR inhibitor-resistant non-small cell lung cancer. 5FU: 5-Fluorouracil; BRAF: v-Raf murine sarcoma viral oncogene homolog B1; EGFR: epidermal growth factor receptor