Fig. 2

lncRNAs and circRNAs have versatile modes of action: A Guide lncRNAs can interact with regulatory proteins (such as epigenetic activators, epigenetic repressors or transcription factors) and direct them to their target regions. B Decoy lncRNAs and circRNAs can bind and sequester miRNAs or proteins. C Scaffold lncRNAs can function as a central platform to allow the assembly of various molecular components to facilitate their intermolecular interactions. D Enhancer RNAs are a class of ncRNAs that are transcribed from enhancer regions and act in regulating mRNA transcription. E mRNA-binding lncRNAs can bind to mRNAs and enhance or reduce its stability