Table 4 Selected list of ncRNAs as potential therapeutic targets

MesomiR 1 (miR-16 mimics)

miRNA

Malignant Pleural Mesothelioma, Non-Small Cell Lung Cancer

Non-living bacterial minicells

Phase I (NCT02369198), Completed

[195]

Cobomarsen /MRG-106 (anti–miR-155)

miRNA

Cutaneous T-Cell Lymphoma/Mycosis Fungoides

LNA-modified antisense inhibitor

Phase II (NCT03713320), Terminated

[196]

MRX34 (miR-34 mimic)

miRNA

Multiple Solid Tumors

Lipid nanoparticles

Phase I (NCT01829971), Terminated

[197]

miR-34 and let-7 mimics

miRNA

Non–Small Cell Lung Cancer

Encapsulated in neutral lipid emulsion

Pre-clinical (Transgenic)

[198]

miR-199a/b-3p mimics and antimiR-10b

miRNA

Hepatocellular Carcinoma

Polymer-based nanoplatform

Pre-clinical (xenograft and patient-derived xenograft)

[199]

antagopiR54265

piRNA

Colorectal Adenocarcinoma

2ʹ-O-methoxyethy modified and 5′-cholesterol-conjugated piRNA inhibitor

Pre-clinical (xenograft)

[200]

anti-SNORA23

snoRNA

Pancreatic Ductal Adenocarcinoma

Antisense oligonucleotide

Pre-clinical (xenograft)

[201]

anti-Leu3′tsLNA

tsRNA

Hepatocellular Carcinoma

LNA-modified antisense inhibitor

Pre-clinical (patient-derived xenograft)

[202]

ARLNC1

lncRNA

Prostate Cancer

Antisense oligonucleotide

Pre-clinical (xenograft)

[203]

LINK-A

lncRNA

Breast Cancer

LNA-modified antisense inhibitor

Transgenic

[204]

SAMMSON

lncRNA

Melanoma

GapmeR

Pre-clinical (patient-derived xenograft)

[205]

MALAT1

lncRNA

Lung And Breast Cancer

Antisense oligonucleotide

Pre-clinical (xenograft and Transgenic)

[206,207,208]

circ-133

circRNA

Colorectal Cancer

Exosome-mediated delivery

Pre-clinical (xenograft)

[174]

circPTK2

circRNA

Colorectal Cancer

Lentivirus

Pre-clinical (patient-derived xenograft)

[161]

circAGO2

circRNA

Gastric Adenocarcinoma

Lentivirus

Pre-clinical (xenograft)

[209]

CircLONP2

circRNA

Colorectal Cancer

Antisense oligonucleotide

Pre-clinical (xenograft)

[210]