Fig. 4

CircPAK1 promotes the apoptosis and angiogenesis of HCC cells. A The percentage of apoptotic cells of STK39 stable knockdown or overexpression cells was analyzed by Annexin V-FITC/PI staining assay. B HUVEC tube formation, migration and invasion were evaluated using the conditioned medium (CM) from LM3 (circPAK1 knockdown) and Hep-3B (circPAK1 overexpression) cells, scale bar, 100 μm. *p < 0.05; **p < 0.01; ***p < 0.001. Data were shown as mean ± SEM