Fig. 2
From: Role of TET dioxygenases in the regulation of both normal and pathological hematopoiesis
The roles of TETs in the pathogenesis of human hematopoietic malignancies. Studies of human hematopoietic malignancies suggested that TET2 is a tumor suppressor for almost all types of hematopoietic malignancies, while TET1 is a tumor suppressor for B-cell malignancies but a tumor promotor for myeloid or T-cell malignancies. TET3 is required for the survival and proliferation of myeloid malignancies. However, its role in T- and B-cell malignancies has yet to be determined. (Created with BioRender.com)