Fig. 8From: Exosomal circZNF451 restrains anti-PD1 treatment in lung adenocarcinoma via polarizing macrophages by complexing with TRIM56 and FXR1The diagram of this study. The LUAD derived exosomal circZNF451 could interact with FXR1 and TRIM56 and facilitate the ubiquitination of FXR1, which abrogates the inhibition on the downstream ELF4-IRF4 pathway and induces the pro-inflammatory phenotype of macrophages and the dysfunction of CD8+T cellsBack to article page