Fig. 2

Schematic illustration of model simulations of ion channel activation and inactivation during cell cycle progression, resulting in abnormal depolarization or hyperpolarization of the membran potental. A Simulation of TASK-1 channel blockage in G1 phase. B Simulation of Kv1.3 channel blockage in a) G1 phase and b) during transition from G1 to S phase. C Simulation of Kv7.1 channel blockage starting at G1 phase. D Simulation of KCa3.1 channel blockage during G1-S transition. E Simulation of TRPC6 channel blockage in a) G0 phase and b) during transition from S to G2/M phase. The symbol + means activation,—means inactivation of ion channels. This was taken from Langthaler S & Baumgartner C et al. [2]