Table 2 Treatment-related adverse events (TRAEs) identified by investigators
| Â | Grade 1 | Grade 2 | Grade 3 | Grade 4 | ||||
|---|---|---|---|---|---|---|---|---|
| Â | No | % | No | % | No | % | No | % |
All patients with an event | 10 | 43.5 | 8 | 34.8 | 3 | 13.0 | 2 | 8.7% |
Asthenia or fatigue | 4 | 17.4 | 1 | 4.3 | 1 | 4.3 | 0 | 0.0 |
Nausea | 2 | 8.7 | 3 | 13.0 | 1 | 4.3 | 0 | 0.0 |
Vomiting | 2 | 8.7 | 3 | 13.0 | 1 | 4.3 | 0 | 0.0 |
Decreased appetite or anorexia | 6 | 26.1 | 2 | 8.7 | 1 | 4.3 | 0 | 0.0 |
Constipation | 1 | 4.3 | 2 | 8.7 | 0 | 0.0 | 0 | 0.0 |
Diarrhea | 1 | 4.3 | 0 | 0.0 | 0 | 0.0 | 1 | 4.3 |
Rash | 1 | 4.3 | 2 | 8.7 | 1 | 4.3 | 0 | 0.0 |
Paresthesia | 1 | 4.3 | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 |
Anemia | 1 | 4.3 | 1 | 4.3 | 0 | 0.0 | 0 | 0.0 |
Increased aminotransferase | 3 | 13.0 | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 |
Increased creatinine | 1 | 4.3 | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 |
Hyperglycemia | 1 | 4.3 | 0 | 0.0 | 0 | 0.0 | 1 | 4.3 |
Neutropenia | 0 | 0.0 | 1 | 4.3 | 2 | 8.7 | 0 | 0.0 |
Febrile neutropenia | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 | 1 | 4.3 |