Fig. 2

Decreased drug sensitivity of organoids in co-culture with matched CAFs. A, B Cell death of PDAC organoids induced by gemcitabine, 5-FU and paclitaxel was significantly reduced when co-cultured with CAFs. The mean values of the two independent replicates for each line are displayed. Paired t-test, * P < 0.05, ** P < 0.01. C, D Proliferation inhibition induced by gemcitabine in PDAC organoids was significantly reduced in co-culture (AUCpi, max. PI). For 5-FU, a significantly lower max. PI was observed for PDAC organoids in co-culture. The mean values of the two independent replicates for each line are displayed. Paired t-test, * P < 0.05