Fig. 2
From: Dose fractionation of CAR-T cells. A systematic review of clinical outcomes
Model showing cytokine levels and toxicity with single dose and fractionated dose. At a constant dose and tumor burden (high), the administration of CAR-T cells as a single infusion can result in the peak cytokine levels that correlate with severe CRS whereas administration of CAR-T cells as 2 or 3 doses can result in lower cytokine levels that correlate with mild-to-moderate CRS.