Table 4 Most frequent treatment emergent adverse events (n = 57 patients)
Adverse Event | Grade 1 n (%) | Grade 2 n (%) | Grade 3 n (%) | Grade 4 n (%) | Total n (%) |
|---|---|---|---|---|---|
Fatigue | 20 (35.1) | 10 (17.5) | 1 (1.8) | 0 | 31 (54.4) |
Headache | 13 (22.8) | 6 (10.5) | 2 (3.5) | 0 | 21 (36.8) |
Seizure | 2 (3.5) | 10 (17.5) | 7 (12.2) | 0 | 19 (33.0) |
Nausea | 11 (19.3) | 6 (10.5) | 0 | 0 | 17 (29.8) |
Focal weakness | 3 (5.3) | 8 (14.0) | 5 (8.7) | 0 | 16 (28.1) |
Thrombocytopenia | 5 (8.7) | 4 (7.0) | 2 (3.6) | 2 (3.6) | 13 (22.8) |
Insomnia | 8 (14) | 4 (7.0) | 0 | 0 | 12 (21.0) |
Vomiting | 7 (12.2) | 4 (7.0) | 0 | 0 | 11 (19.3) |
Abdominal pain | 8 (14.0) | 2 (3.5) | 1 (1.8) | 0 | 11 (19.3) |
Fall | 6 (10.5) | 1 (1.8) | 1 (1.8) | 2 (3.5) | 10 (17.5) |
Dizziness | 8 (14.0) | 2 (3.5) | 0 | 0 | 10 (17.5) |
Cerebral edema | 0 | 1 (1.8) | 6 (10.5) | 2 (3.5) | 9 (15.8) |
Injection-site reaction | 8 (14.0) | 1 (1.8) | 0 | 0 | 9 (15.8) |
Myalgia | 5 (8.7) | 3 (5.3) | 0 | 0 | 8 (14.0) |
Depression | 4 (7.0) | 4 (7.0) | 0 | 0 | 8 (14.0 |
Neutropenia | 0 | 2 (3.5) | 4 (7.0) | 1 (1.8) | 7 (12.2) |
DVT/PE | 0 | 3 (5.3) | 4 (7.0) | 0 | 7 (12.2) |
Flu-like symptoms | 6 (10.5) | 1 (1.8) | 0 | 0 | 7 (12.2) |
Confused/Forgetful | 2 (3.5) | 3 (5.3) | 1 (1.8) | 0 | 6 (10.5) |
Bone pain | 6 (10.5) | 0 | 0 | 0 | 6 (10.5) |
Pruritis | 6 (10.5) | 0 | 0 | 0 | 6 (10.5) |